Ofufuzawo apeza kuti metabolite yoyamba ya thc imakhalabe ndi nyongolotsi kuchokera ku mitundu ya mbewa. Zambiri zatsopano zikuwonetsa kuti wamkulu wa metabolite wosuta mkodzo ndi magazi akhoza kukhalabebe komanso othandiza monga thc, ngati sichoncho. Kupeza kwatsopano kumeneku kumabweretsa mafunso ambiri kuposa momwe amayankha. Malinga ndi kafukufuku waposachedwa yemwe adafalitsidwa mu nyuzipepala ya pharmacology ndikuyesera ma psychoactite ya thc, hydroxy-thcroxy-thc (descho-9 thc).
Phunziroli, lobatizidwira "kuledzera kwa 11-hydroxy-hydroxy-delta-9-thc (11-O Ndizodziwika bwino kuti Thc imasweka ndikupanga zinthu zatsopano zochititsa chidwi zikakhala zaka makumi atatu ndi zochita za munthu. "Phunziroli, tinatsimikiza kuti metabolite yoyamba ya thc, 11-Oh-thc, ziwonetsero zofanana kapena zopitilira munjira zoyendetsera, kugonana, pharmacokinetics," Pharmandsics, "Pulogalamuyi. "Zolemba izi zimapereka malingaliro ofunikira pakupanga kwachilengedwe kwa thc metabolites, dziwitsani zamtsogolo kafukufuku wamkati, ndipo mwachitsanzo, kagayidwe kathu ndi kagayini zimakhudza kugwiritsa ntchito cannobis ya anthu."
Kafukufukuyu adachitidwa ndi gulu lochokera ku Saskatchewan, kuphatikiza Ayat Zagzoog, Alarna M. Alexis Wilcox, Anyart B. Lapraie. Poyesera, ofufuza adalowetsa makoswe aamuna ndi 11-hydroxy-hyc ndipo adawona ndikuphunzira zotsatira za metabolite iyi poyerekeza ndi Pakudya Zake, Delta-9 thc.
Ofufuzawo adazindikiranso kuti:
Chifukwa chake, kafukufukuyu akusonyeza kuti thc metabolite 11-Oh-thc atha kutenga mbali yofunika kwambiri pazinthu zachilengedwe za cannabis. Kumvetsetsa ntchito yake pamene kuperekedwa mwachindunji kumathandizira kufotokozera maphunzilo amtsogolo ndi maphunziro a anthu. Lipotilo limatchulapo kuti 11-Oh
Malinga ndi US Centers kuwongolera matenda ndi kupewa (CDC), koyambirira kwa ma 1980s, mayeso a mkondo, 9-thc.
Lipotilo likuwonetsa kuti ngakhale kusuta cannabis nthawi zambiri kumabweretsa zovuta mwachangu kuposa ma cannabis okwanira Ripotilo likusonyeza kuti ichi ndi chifukwa chimodzi chomwe chimapangitsa kuti zakudya zomwe zasandukidwezo zimatha kukhala psychoactive ndi kuyambitsa chisokonezo.
Thc metabolites ndi kuyezetsa mankhwala osokoneza bongo
Umboni ukusonyeza kuti Cannabis imakhudza ogwiritsa ntchito mosiyana ndi njira ya makonzedwe. Phunziro la 2021 lomwe linasindikizidwa m'bulono lokhazikika linasonyeza kuti zovuta zomwe zimayambitsa zovuta za cannabis ndizokulirapo kuposa kagayidwe ka 11-Oh-thc.
"Bioavailability ya thc kudzera pa Vaporrization ndi 10% mpaka 35%," ofufuzawo adalemba. "Pambuyo pa mayamwidwe, Thc alowa chiwindi, komwe ambiri amachotsedwa kapena kuphatikizidwa mu 11% yokha mpaka 12%. Hafu ya moyo wa ogwiritsa ntchito nthawi zina ndi masiku 1 mpaka atatu, pomwe odwala kwambiri, amatha kutalika mpaka masiku 5 mpaka 13. "
Kafukufuku akuwonetsa kuti nthawi yayitali zotsatira za psychoactive zotsatira za cannabis zatha, thc metabolites ngati 11-O-thc imatha kukhalabe m'magazi ndi mkodzo kwa nthawi yayitali. Izi zimabweretsa zovuta njira zoyeserera ngati oyendetsa ndi othamanga amalephera kugwiritsa ntchito chifukwa cha cannabis. Mwachitsanzo, ofufuza ku Australia akhala akuyesera kudziwa nthawi yomwe ma can cannabis angawononge ntchito yoyendetsa. Nthawi ina, Thomas R. Arkell, Danielle McCartney, ndi Iain S. McGreer kuchokera ku yunivesite ya Sydney adagwiritsa ntchito mphamvu yakuyendetsa. Timuyo anaganiza kuti cannabis imalepheretsa kuyendetsa galimoto kwa maola angapo atasuta, koma zofooka izi zimatha pamaso pa ma metabolites a thc zimayeretsedwa ndi magazi kwa milungu kapena miyezi ingapo.
"Odwala pogwiritsa ntchito zinthu za thc-wokhala ndi kuyendetsa galimoto ndi ntchito zina zotetezeka (mwachitsanzo, makina olemba woyamba," olemba adalemba. "Ngakhale odwala sakhala ndi vuto, angayeserenso zabwino za thc. Komanso, odwala cannobis cannobis pano sakusiyidwa ndi zoyeserera zam'manja komanso zovomerezeka."
Kafukufuku watsopanoyu pa 11-O Ohc akuwonetsa kuti maphunziro ambiri amafunika kumvetsetsa kwambiri momwe ma mec metabolites amakhudzira thupi la munthu. Pokhapokha tikangoyesetsa kupitiliza zinsinsi za zinthu zapaderazi.
Post Nthawi: Mar-21-2025