Ofufuza apeza kuti metabolite yoyambirira ya THC imakhalabe yamphamvu kutengera deta yamitundu ya mbewa. Deta yatsopano yofufuza ikuwonetsa kuti metabolite yayikulu ya THC yotsalira mumkodzo ndi magazi ingakhalebe yogwira ntchito komanso yothandiza ngati THC, ngati sichoncho. Kupeza kwatsopano kumeneku kumabweretsa mafunso ambiri kuposa momwe kumayankhira. Malinga ndi kafukufuku waposachedwa wofalitsidwa mu Journal of Pharmacology and Experimental Therapeutics, psychoactive metabolite ya THC, 11-hydroxy-THC (11-OH-THC), ili ndi mphamvu yofanana kapena yochulukirapo kuposa THC (Delta-9 THC).
Kafukufukuyu, wotchedwa "The Intoxication Equivalence of 11-Hydroxy-Delta-9-THC (11-OH-THC) Relative to Delta-9-THC," akuwonetsa momwe THC metabolites imasungira ntchito. Ndizodziwika bwino kuti THC imasweka ndikupanga zinthu zatsopano zochititsa chidwi ikatulutsa decarboxylate ndikuchita m'thupi la munthu. "Mukafukufukuyu, tidatsimikiza kuti metabolite yayikulu ya THC, 11-OH-THC, ikuwonetsa ntchito yofanana kapena yokulirapo kuposa THC mu mbewa cannabinoid ntchito yachitsanzo ikayendetsedwa mwachindunji, ngakhale poganizira kusiyana kwa njira zoyendetsera, kugonana, pharmacokinetics, ndi pharmacodynamics," kafukufukuyu akuti. "Zidziwitso izi zimapereka chidziwitso chofunikira pazachilengedwe za metabolites ya THC, kudziwitsa za kafukufuku wamtsogolo wa cannabinoid, ndikuwonetsa momwe madyedwe a THC ndi kagayidwe kachakudya zimakhudza kugwiritsa ntchito chamba."
Kafukufukuyu anachitidwa ndi gulu la Saskatchewan, Canada, kuphatikizapo Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, ndi Robert B. Laprairie. Pakuyesaku, ofufuza adabaya makoswe aamuna ndi 11-hydroxy-THC ndipo adawona ndikuwerenga zotsatira za metabolite ya THC iyi poyerekeza ndi gawo la makolo ake, Delta-9 THC.
Ofufuzawo adanenanso kuti: "Deta iyi imasonyeza kuti muyeso-mchira-flick kuti muzindikire ululu, ntchito ya 11-OH-THC ndi 153% ya THC, ndi mayesero a catalepsy, ntchito ya 11-OH-THC ndi 78% ya THC. Choncho, ngakhale kuganizira kusiyana kwa pharmacokinetic, ngakhale kuwonetsetsa kwakukulu kwa pharmacokinetic-THC-THC-pawiri-THC11 THC."
Chifukwa chake, kafukufukuyu akuwonetsa kuti THC metabolite 11-OH-THC itha kutenga gawo lofunikira pazachilengedwe za cannabis. Kumvetsetsa momwe ntchito yake ikugwiritsidwira ntchito mwachindunji kungathandize kufotokoza maphunziro amtsogolo a nyama ndi anthu. Lipotilo limatchula kuti 11-OH-THC ndi imodzi mwama metabolites awiri oyambilira omwe amapangidwa pambuyo pomwa chamba, winayo ndi 11-nor-9-carboxy-THC, yemwe sakhala ndi psychoactive koma amatha kukhalabe m'magazi kapena mkodzo kwa nthawi yayitali.
Malinga ndi US Centers for Disease Control and Prevention (CDC), koyambirira kwa zaka za m'ma 1980, kuyezetsa mkodzo kumayang'ana makamaka 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite ya Delta-9-THC, yomwe ndi gawo lalikulu la chamba.
Lipotilo likuwonetsa kuti ngakhale kusuta chamba kumabweretsa zotsatira mwachangu kuposa zomwe zimadyedwa chamba, kuchuluka kwa 11-OH-THC komwe kumapangidwa ndikumwa ndikokulirapo kuposa kusuta maluwa a cannabis. Lipotilo likuwonetsa kuti ichi ndi chifukwa chimodzi chomwe zakudya zolowetsedwa ndi cannabis zimatha kukhala zosokoneza komanso kuyambitsa chisokonezo kwa omwe sanakonzekere.
THC Metabolites ndi Kuyesa Mankhwala
Umboni ukuwonetsa kuti cannabis imakhudza ogwiritsa ntchito mosiyanasiyana kutengera njira yoyendetsera. Kafukufuku wa 2021 wofalitsidwa mu Permanent Journal adawonetsa kuti zotsatira za kudya chamba edibles ndizokulirapo kuposa kusuta chamba chifukwa cha metabolism ya 11-OH-THC.
"The bioavailability ya THC kudzera mu vaporization ndi 10% mpaka 35%," ofufuza adalemba. "Pambuyo pa kuyamwa, THC imalowa m'chiwindi, kumene ambiri amachotsedwa kapena amapangidwa ndi 11-OH-THC kapena 11-COOH-THC, ndi THC yotsalira ndi metabolites ake amalowa m'magazi. Nthawi zambiri, theka la moyo wa plasma wa THC mwa ogwiritsa ntchito mwa apo ndi apo ndi tsiku limodzi mpaka 3, pomwe ogwiritsa ntchito osatha, amatha kukhala masiku 5 mpaka 13.
Kafukufuku akuwonetsa kuti pakapita nthawi yayitali mphamvu ya psychoactive ya cannabis yatha, ma metabolites a THC ngati 11-OH-THC amatha kukhalabe m'magazi ndi mkodzo kwa nthawi yayitali. Izi zimabweretsa zovuta panjira zoyeserera ngati oyendetsa ndi othamanga ali ndi vuto chifukwa chogwiritsa ntchito chamba. Mwachitsanzo, ofufuza aku Australia akhala akuyesera kudziwa nthawi yomwe cannabis ingasokoneze kuyendetsa bwino. Nthawi ina, Thomas R. Arkell, Danielle McCartney, ndi Iain S. McGregor ochokera ku Lambert Initiative ku yunivesite ya Sydney adaphunzira momwe cannabis imakhudzira luso loyendetsa galimoto. Gululo lidatsimikiza kuti cannabis imalepheretsa kuyendetsa bwino kwa maola angapo mutasuta, koma zofookazi zimatha ma metabolites a THC asanachotsedwe m'magazi, ma metabolites amapitilirabe m'thupi kwa milungu kapena miyezi.
"Odwala omwe amagwiritsa ntchito mankhwala omwe ali ndi THC ayenera kupewa kuyendetsa galimoto ndi ntchito zina zotetezeka (mwachitsanzo, makina ogwiritsira ntchito), makamaka panthawi yoyamba ya chithandizo komanso kwa maola angapo pambuyo pa mlingo uliwonse," olembawo analemba. "Ngakhale odwala sakumva kuti ali ndi vuto, atha kuyezetsa kuti ali ndi THC. Komanso, odwala cannabis pakali pano saloledwa kuyezetsa mankhwala amtundu wa m'manja ndi zilango zina."
Kafukufuku watsopano wa 11-OH-THC akuwonetsa kuti maphunziro ochulukirapo akufunika kuti amvetsetse momwe ma metabolites a THC amakhudzira thupi la munthu. Pokhapokha pokhapokha pokhapo tingathe kuulula zinsinsi zamagulu apaderawa.
Nthawi yotumiza: Mar-21-2025